Although current evidence demonstrated that supplementation with BCAAs such as leucine, valine, and isoleucine could ameliorate protein synthesis, lipid, and glucose metabolism, as well as insulin resistance and hepatocyte proliferation, in addition, reduce oxidative stress in hepatocytes in liver cirrhosis, several published studies reported no significant improvement in muscle strength or mass post-intervention with BCAA supplementation (51, 65). Here, INS is linked to cirrhosis of liver.