In the full RA+AS cohort, ACE2 activity significantly increased after 6 M (41.1 [35–70] UF/mL; p = 0.044) and 12 M (44.7 [34–57] UF/ml; p = 0.010) compared to B (42.8 [31–53] UF/mL). Here, ACE2 is linked to rheumatoid arthritis.