Furthermore, the death receptor Fas and its specific ligand (Fas-L), is overexpressed and correlates with the rate of apoptosis in MDS (Bouscary et al., 1997; Gersuk et al., 1998; Gupta et al., 1999), induces inflammasome independent non-canonical IL-1β and IL-18 maturation and cell death via caspase-8 (Bossaller et al., 2012). The gene discussed is IL1B; the disease is myelodysplastic syndrome.