The results revealed that the expression level of PCOLCE2 and HOXC11 in COAD patients was significantly higher than that in healthy individuals, regardless of for M tumor stage, lymph node metastasis and peritoneal metastasis (p < 0.05) (Supplementary Figures S2B–D,F–H). This evidence concerns the gene HOXC11 and colon adenocarcinoma.