Interestingly, the activation of transcription factor YAP1 could promote the susceptibility of tumor cells to ferroptosis by controlling the expression of ferroptosis modulatory factors such as TFRC, EMP1, ACSL4, and ANGPTL4 (Viswanathan et al., 2017; Wu et al., 2019), which suggests that ferroptosis-inducing drugs may be a perfect treatment for YAP1-activated tumors. The gene discussed is ACSL4; the disease is neoplasm.