In another study, downstream targets of GAS5, including tumor-suppressor genes (e.g., TP53, Bax, and Bim) as well as oncogenes (e.g., TGFB, DDB2, and ROS1), were identified (Zhang, Hu et al., 2019), further highlighting the roles of GAS5 in osteosarcoma. This evidence concerns the gene GAS5 and neoplasm.