Therefore, PKG is involved in many cellular functions, including differentiation, apoptosis, relaxation, remodeling, hypertrophy, neuronal plasticity, platelet aggregation, protein degradation, and erectile dysfunction (Hedlund et al., 2000; Persson et al., 2000; Schlossmann and Desch, 2011; VerPlank et al., 2020). Here, PRKG1 is linked to erectile dysfunction.