This is also supported by the STRING subnetwork among network signature genes and drug-target genes (Figure 4H), where TUBB1, TOP1, and EGFR can interact with a group of network signature genes enriched in the functional pathway “Pathways in cancer” and MDM2 and CKD4 can cooperate with another group of network-neighbor genes enriched in the functional pathway “Chronic myeloid leukemia”. This evidence concerns the gene TOP1 and chronic myelogenous leukemia, BCR-ABL1 positive.