Furthermore, the patients were divided into two groups (the “writers” mutation group and the non-mutation group), and enrichment analysis via GSVA revealed that tumor hallmarks associated gene sets, including the KRAS signaling pathway, DNA repair pathway, and the PI3K/AKT/MTOR signaling pathway, were mainly enriched in “writers” mutation group (Supplementary Figure S2C). The gene discussed is AKT1; the disease is neoplasm.