It has been shown that upon oxygen deprivation, a fraction of MDM2 localizes to the mitochondria in p53-independent manner, inhibits mitochondrial respiration by reducing complex I subunit NADH-dehydrogenase 6 (MT-ND6), enhances reactive oxygen species (ROS) production, and promotes cancer cell migration and invasion (Arena et al., 2018). The gene discussed is MDM2; the disease is cancer.