TP53 and cancer: A master regulator of systemic homeostasis, p53 regulates pathogenesis of many diseases other than cancer, including neurodegeneration, cardiovascular diseases, metabolic disorders, autoimmune and infectious diseases (Takatori et al., 2014; Siegl and Rudel, 2015; Kung and Murphy, 2016; Szybinska and Lesniak, 2017; Aloni-Grinstein et al., 2018; Maor-Nof et al., 2021; Men et al., 2021).