Similar paradoxical regulations between cancer susceptibility and metabolic fitness have been linked to other SNPs in p53-MDM2 pathway, including Proline72Arginine (P72R; rs1042522) and Proline47Serine (P47S; rs1800371) of p53 (Kung et al., 2015; Jennis et al., 2016; Kung et al., 2016; Kung et al., 2017; Gnanapradeepan et al., 2020). Here, MDM2 is linked to cancer.