IL6 and coronary artery disorder: As such the number of endothelial and platelet derived EVs have been correlated with the circulating levels of IL-6 and CRP in patients with coronary heart disease (Cui et al., 2013); moreover in vitro, medium size vesicles from acute coronary syndrome patients displayed procoagulant activity, which was prevented when phosphatidylserine was blocked with lactadherin (Liu et al., 2016).