A study found that patients with an IL-1 (+) genotype were associated with an increased risk of developing CAVD, whereas patients with an IL-1 (-) genotype were not sensitive to the increased incidence of CAVD mediated by OxPL/apoB or Lp(a) (Tsimikas et al., 2014). The gene discussed is APOB; the disease is congenital bilateral aplasia of vas deferens from CFTR mutation.