Salles et al., (2013); Bouchareb et al., (2015) found that the plasma ATX content and activity in patients with CAVD were higher than those in the control group. Further analysis showed that after adjusting for age and sex, the risk of CAVD increased by 3.5 times in patients with high activity of ATX (≥84RFUmin-1, median) and higher Lp(a) level (≥50 mgdL-1, median), compared with patients with lower activity of ATX and Lp(a) levels. In addition, the risk of CAVD increased by 5.5 times in patients with higher ATX activity and OxPL-apoB (≥2.02 nmol/L, median). (Salles et al., 2013). Here, ENPP2 is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.