ENPP2 and congenital bilateral aplasia of vas deferens from CFTR mutation: It is worth noting that in the process of CAVD, the pro-inflammatory effect of Lp(a) is primarily mediated by OxPL, not only by directly inducing the expression of related inflammatory genes (Serbulea et al., 2018), but also manifested through bone-forming signals (for example, OxPL can indirectly activate IL-6 through the ATX-mediated transduction of NF-κB signaling to promote an AV inflammatory response (Bochkov et al., 2010)).