IL6 and calcification: Pawade et al. (2015); Zheng et al., (2019) also found that a pre-incubation of Lp(a) with the E06 monoclonal antibody could attenuate the osteogenic differentiation of Lp(a)-mediated IL-6 and could further decrease the expression of IL-6, RANKL-11, and valvular calcification after an intervention with 17KΔOxPL r-apo(a). Previous studies have shown that IL-6 can induce the expression of tumor necrosis factor superfamily member 11 (RANKL-11) in osteocytes. (Wada et al., 2006).