TNF and cancer: The related pathways network indicated that angiogenesis scores were significantly involved in cancer-related signaling pathways, including Kras signaling, TGF-beta signaling, apoptosis, IL-2 STAT5 signaling, TNF-a signaling via NFK-b, inflammatory responses, IL-6 JAK STAT3 signaling, notch signaling, and the P53 pathway (Figure 3A).