A steroidal compound, physapubescin B, extracted from Physalis pubescens L. (Solanaceae), has been described to possess anti-cancer potential through excessive ROS generation and induce p53-dependent apoptotic cell death by autophagy inhibition in cervical cancer (HeLa) and colon cancer (HCT116) cells (Xu et al., 2017). Here, TP53 is linked to cancer.