TP53 and cancer: Recently, it has been highlighted that interplay between pro-inflammatory/pro-oncogenic and pro-inflammatory cytokines pathways regulated via UPR signaling as well as autophagy which affects the stability of p53 that is able to control UPR signaling, cytokine release, and autophagy to preserve its own stability in additional to promote tumorigenesis against cancers carrying mutp53 (D'Orazi et al., 2021).