TP53 and colorectal cancer: Quercetin, a flavonoid derived from fruits and vegetables, was found to induce p53-independent/mTORC1 mechanism in various cancer cells such as human hepatocellular carcinoma cells (HepG2, Hep3B, MDA-MB-231) and colorectal cancer cells (HCT116, GFP-LC3 Hela cells) (Wang Z. X. et al., 2021).