POU5F1 and gastric cancer: In addition, Fu et al. transfected tripartite motif-containing 3 (TRIM3) plasmid into gastric cancer cells to acquire TRIM3-overexpressing exosomes and found that these exosomes could downregulate the expression levels of OCT4, SOX2, and N-cadherin of gastric cancer cells, thereby inhibiting the tumor growth in mice (Fu et al., 2018).