Furthermore, Hong et al. verified that milk-derived exosomes carrying Bcl-2-siRNA could efficiently penetrate the cell membrane and suppress the invasion and migration of pancreatic cancer cells by downregulating matrix metalloproteinases 2 (MMP2), MMP9, vimentin, and N-cadherin (Tao et al., 2020). This evidence concerns the gene MMP2 and familial pancreatic carcinoma.