It was found that CTSB was negatively associated with both OS and DFS in brain low-grade glioma (LGG) and mesothelioma (MESO), and negatively correlated with OS in BLCA, breast invasive carcinoma, and glioblastoma multiforme (GBM) (Figures 6A,B). The gene discussed is CTSB; the disease is invasive breast carcinoma.