FOXO1 and neoplasm: Because of these reasons, the anti-tumor effect had particularly attracted widespread attention, GA could inhibit various cancer cell’s growth, including colorectal cancer, breast cancer, liver cancer, lung cancer, etc. (Li et al., 2010; Yan et al., 2012; Zhou et al., 2013; Xu et al., 2018; Zhao et al., 2020), which might be related with modulating the signaling pathways of protein kinase B (AKT)/mammalian target of rapamycin (mTOR), c-Jun N-terminal cvvkinase-1 (JNK-1), nuclear factor kappa-B (NF-κ B), AKT/forkhead box protein O1(FOXO1)/BIM and so on.