Whereas previous work has linked EPCR or dual EPCR and ICAM-1 PfEMP1 variants to severe malaria (Lavstsen et al., 2012; Turner et al., 2013; Bernabeu et al., 2016; Kessler et al., 2017; Storm et al., 2019; Sahu et al., 2021; Wichers et al., 2021), little is known about their endothelial binding specificity. Here, ICAM1 is linked to malaria.