Whereas previous work has established that EPCR and ICAM-1 are receptors on brain endothelial cells (Turner et al., 2013; Avril et al., 2016; Lennartz et al., 2017; Bernabeu et al., 2019; Storm et al., 2019), little is known about parasite tropism for gut and kidney, even though multiorgan complications affecting the brain and kidney are common in severe malaria (Dondorp et al., 2008b; Batte et al., 2021) and the gastrointestinal tract is a major site of sequestration in high burden parasite infections (Dondorp et al., 2008a; Milner et al., 2014). Here, ICAM1 is linked to infection.