Whereas the EPCR binders comprise only a small minority of the var gene repertoire (~10% of genes) (Rask et al., 2010), this subset is transcriptionally elevated in severe malaria infections and both the DC8 and Group A PfEMP1 variants are linked to severe malaria complications (Lavstsen et al., 2012; Turner et al., 2013; Bernabeu et al., 2016; Kessler et al., 2017; Lennartz et al., 2017; Mkumbaye et al., 2017; Sahu et al., 2021; Wichers et al., 2021). Here, NSL1 is linked to malaria.