There is also interplay between autophagy and inflammatory pathways during both Ehrlichia and Rickettsia infection (Tominello et al., 2019; Bechelli et al., 2021), and autophagy induction is balanced by signaling of MyD88 (a downstream adaptor for many pattern recognition receptors) during ehrlichial infection (Kader et al., 2017). This evidence concerns the gene MYD88 and Rickettsiosis.