Through a LASSO regression with 1000-folds cross-validation to identify the optimal lambda value that came from the minimum partial likelihood deviance, we got 8 candidate FRGs (CD44, BID, DRD4, TRIB3, CDKN2A, SLC7A11, TAZ and MIOX) that were significantly associated with the prognosis of ccRCC (Figures 3B, C). Here, CDKN2A is linked to nonpapillary renal cell carcinoma.