The lncRNA AK000053 is a novel hypoxia-inducible that affects the expression of calmodulin CDH1, transcription factor ZEB1, SALL4 and BMI1 through downregulation of miR-508, thereby defining the stem-like/mesenchymal subtype and promoting stemness and metastasis in CRC (85). The gene discussed is CDH1; the disease is colorectal carcinoma.