DIS3L2 and cancer: The DIS3 like 3’-5’ exoribonuclease 2 (DIS3L2), which is closely associated with the Lin28/let-7 pathway in several cancers, was shown to be downregulated by knockdown of lncRNA AC105461.1, which is located upstream of the DIS3L2 promoter, thereby enhancing the stemness of CRC (60, 61).