Consistent with TCGA data, tumor specimens with SMAD4 expression displayed a significant increase in the percent area that stained positive for IFNγ (Figure 6H), and tumors that expressed SMAD4 or PD-L1 demonstrated a highly significant increase in the degree of tumor-infiltrating T-cells that also stained positive IFNγ (Figure 6I). The gene discussed is SMAD4; the disease is neoplasm.