These observations suggest an important role for Sdc-1 in the progression of cervical cancer. The observation of decreased cell motility in Sdc-1 overexpressing HeLa cells (Figure 4) is consistent with clinical data on Sdc-1-dependent lymph node metastasis, as a previous study on 106 tissue specimens showed an inverse correlation between Sdc-1 expression in the primary site of cervical carcinomas and lymph node metastases (15). The gene discussed is SDC1; the disease is cervical carcinoma.