To understand the roles of the wild type (Sdc1-WT), membrane-bound (Sdc1-388), and soluble Sdc-1 (Sdc1-392) in the progression of cervical cancer, the human cervical cancer cell line HeLa was stably transfected with three different Sdc-1 DNA constructs and a control vector (Figure 2A), as previously described (10). The gene discussed is SDC1; the disease is cervical carcinoma.