As SRC inhibition is suggested to additionally stabilize stromal CAV1 thereby limiting the gain in stromal radioresistance, spheroids consisting of normal LNCaP PCa cells with low endogenous CAV1 levels and of CAV1-expressing HS5 fibroblasts (to mimic the human situation concerning the epithelial-stromal CAV1 distributions at early stage PCa) were treated with RT in the presence or absence of SRC inhibition by dasatinib (Figure 5). This evidence concerns the gene CAV1 and posterior cortical atrophy.