On the one hand, B cells can stimulate anti-tumor immunity by antigen presentation B cell (APC-B cell) and producing IgG (Plasma cell) to mediate antibody-dependent cytotoxicity; on the other hand, regulatory B cells (B-regs) inhibit CD8+ T cell activity by secreting IL-10, PD-L1, and TGF-β, resulting in tumor immunosuppressive effects and tumor progression. The gene discussed is CD274; the disease is neoplasm.