SEMA4D and non-small cell lung carcinoma: Fan Fei-Fei found that MMP-14, sCD100 level decreased and mCD100 increased in non-small cell lung cancer (NSCLC) compared with healthy people, whereas recombinant CD100 or sCD100 upregulation by MMP-14 enhanced CTL activity by secreting IFN-γ and TNF-α.