SEMA4D and pancreatic endocrine carcinoma: However, anti-Sema4D treatment with a specific antibody (Mab67, Vaccinex) shrank tumor bulk and improved survival rates in pancreatic neuroendocrine cancer (RIP1-Tag2) mice in a short period, but conversely promoted lymph node metastasis consistent with an increase in TAMs after anti-Sema4D treatment (49).