Recently, a Phase Ib/II study of pepinemab (anti-Sema4D) in combination with avelumab (anti-PD-L1) showed that the combination therapy was well tolerated and exerted antitumor activity in immunotherapy-resistant and PD-L1-low NSCLC patients (76). The gene discussed is SEMA4D; the disease is non-small cell lung carcinoma.