A variety of signal pathways are involved in the EMT process, such as Wnt, TGF- β (transforming growth factor- β), c-Met and Notch-1 signaling pathways, etc. The Wnt/β-Catenin pathway appears to drive the EMT of HCC, to effectively inhibiting various targets in the Wnt signaling pathway can reduce or reverse the occurrence of tumor EMT. This evidence concerns the gene NOTCH1 and neoplasm.