VEGFA and hepatocellular carcinoma: The CLEC3B can be wrapped inside exosomes and the downregulated exosomal CLEC3B suppressed vascular endothelial growth factors (VEGFs) secretion in both HCC cells and endothelial cells via AMPK (adenosine monophosphate-activated kinase) signal pathway, and eventually inhibited angiogenesis (63).