Upregulated in both serum from HCC patients and HCC cells, the exosomal lincRNA LINC00161 was directly bound to miR-590-3p to upregulate its downstream target gene ROCK2 (Rho-associated protein kinase 2), stimulating cell proliferation, migration and angiogenesis of HUVECs (48). This evidence concerns the gene ROCK2 and hepatocellular carcinoma.