CD274 and neoplasm: Responses appeared to be guided by PD-L1 CPS as one of the most important factors; however, also in case of high PD-L1 CPS, there was a relatively high quote of respondents choosing combination of chemotherapy plus IO, mainly in cases where the high tumor burden (case #1) or the symptoms (mainly pain) complained by the patients justified the need to achieve tumor response (case #2 and #5).