After analyzing the differences in the gene expression of pancreatic cancer tissues between the CD8+ T cell high and low infiltration groups, there were 308 significant DEGs (|log2 FoldChange|>1.0, p <0.05), of which 268 genes were up-regulated in CD8+ T cell high infiltration group and 40 genes were down-regulated (Figures 1E, F and Supplementary Table S1). This evidence concerns the gene CD8A and familial pancreatic carcinoma.