LINC00641 is downregulated in bladder cancer, cervical cancer, breast cancer, prostate cancer, non-small cell lung cancer, glioma and cutaneous squamous cell carcinoma, and can be used as a tumor suppressor gene, while it is up-regulated in acute myeloid leukemia, gastric cancer, rectal cancer and renal cell carcinoma, and can be used as oncogene. This evidence concerns the gene LINC00641 and hereditary clear cell renal cell carcinoma.