Since the team of Sato successfully cultured Lgr5 intestinal stem cells into crypt-villus structures of the small intestine in vitro in 2009 (11) and patient-derived organoids (PDOs) in colon cancer in 2011 (12), many research teams have successively studied epithelial enriched tumor organoids such as liver (13), pancreas (14), esophagus (15), and stomach (16) and found that these models match well with the original tumor. The gene discussed is LGR5; the disease is neoplasm.