HOXA11-AS is thought to bind directly to LSD1, EZH2, WDR5, STAU1, DNMT1 and AGO2 in tumor cells, acting as a frame for EZH2 and LSD1/DNMT1 to downregulate PRSS8, KLF2 and P21 expression, thus promoting GC. The gene discussed is KDM1A; the disease is gastric cancer.