GATA6-AS1 can downregulate the expression of FZD4 by specifically recruiting and binding with EZH2 to increase the enrichment of H3K27me3 in the region FZD4 promoter, which in turn inhibits the Wnt/β-catemin downstream pathway, ultimately leading to the blockage of GC progression (112). This evidence concerns the gene FZD4 and gastric cancer.