In previous research, TME infiltration of 1524 GC patients was broadly gauged and divided into three TME types with unique genomic and clinicopathologic features: the high TMEscore defined by immune activation and response to virus and IFN-γ was constructed, while the low TMEscore was characterized by stimulation of transforming growth factor β, epithelial–mesenchymal transition, and angiogenesis pathways (9). Here, IFNG is linked to gastric cancer.