Furthermore, these natural compounds affect upstream regulators to arrest tumor cells via different pathways, including the PIK3/Akt (45–48), p38 mitogen-activated protein kinase (MAPK) (46, 51), p53 (46, 47, 52–54), Ras/Raf/ERK (47) and NF-κB pathways (53). This evidence concerns the gene AKT1 and neoplasm.