mTORC2 is responsive to growth factor signaling via phosphorylating downstream V-Akt murine thymoma viral oncogene homolog (AKT), Serum and glucocorticoid-regulated kinase (SGK); it also plays a vital role in the maintenance of normal and cancer cells by associating with ribosomes and participating in cellular metabolic regulation (10). The gene discussed is SGK1; the disease is cancer.