PRTN3 and microscopic polyangiitis: AAV: Anti-neutrophil cytoplasmic antibody-associated vasculitis; GCs: Glucocorticoids; CYC: Cyclophosphamide; MP: Methylprednisolone; ANCA: Anti-neutrophil cytoplasmic antibody; PR3-ANCA: Proteinase 3– ANCA; GPA: granulomatosis with polyangiitis; MPA: microscopic polyangiitis; PLEX: Plasma exchange; ESRD: End-stage renal disease; ADVOCATE: A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis