These results are consistent with previous RNAseq studies (Methodology and Supplementary Fig. S1A and B) and captures the well-characterized transcriptome markers for psoriasis, such as members of the EDC (e.g. S100A12, S100A7A and LCE3E), defensin (e.g. DEFB4A), SERPIN (e.g. SERPINB4) gene families [28–30, 36]. The gene discussed is LCE3E; the disease is psoriasis.