It is recommended to conduct the future trials to investigate the impact of the nanomicelle curcumin, Nigella sativa, and their combination on other bone turnover biomarkers especially C‐terminal telopeptide of type 1 collagen (CTX) and procollagen type 1 aminoterminal propeptide (P1NP) as reference bone resorption and formation biomarkers, respectively, in osteoporosis (Vasikaran et al., 2011). Here, CYP27A1 is linked to osteoporosis.