PIM3 and PIK3C3 in breast cancer, PIM3 and PTEN in breast, kidney, and ovarian cancer, and PIM3 and PTEN in prostate cancer Malignancies of the liver and thyroid, as well as cancers of the breast and ovary, have been linked to PIK3C3 and PTEN mutations in the past. The gene discussed is PIK3C3; the disease is breast cancer.