As depicted in Tables 1 and 2, there are 13 common central proteins (those characterized with higher values of central parameters) (65% similarity) between diabetes mellitus and fatty liver disease: INS, IL6, AKT1, PPARG, ALB, GAPDH, ADIPOQ, LEP, TNF, TP53, SIRT1, IGF1, and MAPK3. The gene discussed is SIRT1; the disease is diabetes mellitus.