To identify genetic factors for CRC, two variants within the intron 4 and the 3’ untranslated region (UTR) of the IL-22 gene, rs1179251 and rs1179246 (located at chromosome 12) and two variants in the intron 6 and 3’near gene of the IL-22Rα gene, rs4648936 and rs10794665 (located at chromosome 1) with the risk of CRC were evaluated. This evidence concerns the gene IL22 and colorectal carcinoma.