TNFAIP3 and primary biliary cholangitis: Moreover, other non-HLA genes responsible in signaling pathways can be considered as allelic risk factors of PBC, such as IL-12 production and antigen presenting process (e.g., IRF5, NF-kB, TNFAIP3, NF-kB, SOCS1, and IL-12A), T cell stimulating and secretion of IFN-γ (e.g., IL12R, TNFSF15, TYK2, TNFAIP3, and STAT4).