We defined the selection criteria for MeCP2 target regions and characterized two groups resulting from the initial analysis: group1 was defined as the common target regions between the WT and APP/PS1 groups, and group2 was defined as AD-specific target regions selected on the basis of > 1.7-fold enrichment specific to the APP/PS1 group compared to the WT group. Here, PSEN1 is linked to Alzheimer disease.