GDNP PA can prevent phosphorylation of Foxa2 by inhibiting Akt-1 activation, however, it is unlikely that GDNP PA is fully responsible for prevention of HFD induced obesity and insulin resistance since more than one factor is dysregulated and contributes to the development of this pathological phenotype. The gene discussed is FOXA2; the disease is obesity due to melanocortin 4 receptor deficiency.