Although sotorasib (LumakrasTM), an inhibitor specifically targeting glycine to cysteine (G12C) missense mutations has been approved by US FDA, to date, there are arduous challenges to develop molecular targeted therapies against other KRAS mutations due to the special protein structure and biochemical properties of KRAS, making the strategy of targeting drug delivery into KRAS mutant cancer cells an attractive alternate 21. Here, KRAS is linked to cancer.