Although enhanced albumin degradation was observed in KRAS mutant tumor cells, as revealed by DQ-BSA (a probe that displays fluorescence after degradation) 16, it is difficult to precisely quantify the contribution of the intrinsic differences in lysosomal function due to the enhanced upstream albumin uptake, as well as the dynamic interaction between macropinosomes and lysosomes. The gene discussed is ALB; the disease is neoplasm.