MIA PaCa-2, a human pancreatic cancer cell line with a homozygous KRASG12C allele, displayed appreciably higher macropinocytosis levels as measured by 70 kDa dextran uptake compared to another pancreatic cell line with wild-type KRAS (i.e. BxPC-3) 16,25. Here, KRAS is linked to familial pancreatic carcinoma.