Therefore, in numerous studies, many drugs that target the enzymes and transporters involved in glucose metabolism, such as hexokinase (HK), lactate dehydrogenase A (LDHA), glucose transporter 1 (GLUT1), and monocarboxylate transporter 1 (MCT1), had been utilized to inhibit glycolysis for cancer therapy 7-11. The gene discussed is LDHA; the disease is cancer.