Interestingly, we found that the CTNNAL1 plus KLF5 2-gene signature could distinguish NSCLC patients with poor survival better than either the CTNNAL1-only or KLF5-only signature (hazard ratio [HR] = 1.94, log-rank P = 0.005) (Figure 6I). The gene discussed is KLF5; the disease is non-small cell lung carcinoma.