Consistently, silencing IGF1R or PTK2 decreased tumor growth in the liver, the occurrence of pulmonary metastasis, and the number of pulmonary metastasis lesions, resulting in prolonged OS of nude mice bearing orthotopic xenografts of PLC/PRF/5-LV-BACH1 cells (Figure 3D-I). The gene discussed is HSPG2; the disease is neoplasm.