Moreover, MUC1-C could block the eIF4A cap-dependent translation of TIGAR, and GO-203 could induce the suppression of TIGAR by inhibiting the MUC1-AKT-mTOR-S6K1-eIF4A pathway, further inhibiting the growth of colon cancer cells 41. The gene discussed is TIGAR; the disease is malignant colon neoplasm.