A recent study demonstrated that the increased expression of MUC1-C in androgen-dependent prostate cancer cells can inhibit androgen receptor (AR) axis signaling and induce the neural BRN2 transcription factor in prostate cancer by increasing MYC occupancy on the BRN2 promoter, which further promotes neuroendocrine prostate cancer 39. The gene discussed is POU3F2; the disease is Familial prostate cancer.