In glioblastoma, METTL3 and METTL14 act as tumor suppressors, while FTO and ALKBH5 are oncogenes 26-27; on the contrary, it has been found that METTL3 promotes growth, invasion and translation in lung cancer cells, indicating that the roles of the m6A modification in tumors are complex 28. This evidence concerns the gene METTL3 and neoplasm.