The percentage of positive METTL3 expression was different in each AML subtype, and the order of positive rates from high to low was M5, M4, M1 and M2, respectively from 15,18,19 and 26 samples, one of the two samples from AML-M6 patients was positive and another was negative (Fig. 1B), while all the APL patients (M3 subtype) did not express METTL3, similarly to the leukemia cell lines (Fig. 1C and 1E). Here, METTL3 is linked to acute myeloid leukemia.