Therefore, we assumed that the high expression of METTL3 and METTL14 in AML increases the levels of m6A in mdm2 mRNAs, an upstream inhibitor of p53, causes its expression, lead to inactivation of the p53 pathway, at last resulting in the maintenance of a population of leukemic stem cells. Here, METTL3 is linked to acute myeloid leukemia.