An analysis of the Cancer Genome Atlas research network (TCGA) database in AML has shown that mutations and/or copy number variations of m6A regulatory genes are associated with TP53 mutations in patients with AML; among these, the loss of ALKBH5 copy number is the most common, and has a striking relation with TP5333-34. The gene discussed is ALKBH5; the disease is acute myeloid leukemia.