As METTL3 and METTL14 were the component of m6A methyltransferase complex, we speculated mdm2 mRNA might be the target of m6A, high expression of METTL3 and METTL14 in AML cause the more m6A in mdm2 mRNA and more expression of MDM2 protein, at last, inhibit the p53 and downstream. The gene discussed is MDM2; the disease is acute myeloid leukemia.