METTL3 and lung carcinoma: In glioblastoma, METTL3 and METTL14 act as tumor suppressors, while FTO and ALKBH5 are oncogenes 26-27; on the contrary, it has been found that METTL3 promotes growth, invasion and translation in lung cancer cells, indicating that the roles of the m6A modification in tumors are complex 28.