We undertook a retrospective analysis of the correlation between ACLY expression in HCC and the therapeutic effect of sorafenib; we found that 32.3% of patients in the group with low ACLY expression had efficacious sorafenib treatment, 14.3% of cases with high ACLY expression had efficacious therapy, and the difference between the two groups was significant. Here, ACLY is linked to hepatocellular carcinoma.