In addition, HSPB2 can bind to p53 to repair its transcriptional activity, so that the repaired p53 can bind to the tumor suppressor RPRM, BAI-1 and TSAP6 promoter regions, and initiate these three genes expression to inhibit the progress of pancreatic cancer cells27. The gene discussed is ADGRB1; the disease is familial pancreatic carcinoma.